FGF23

Across TCGA patient cohorts, FGF23 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF23-associated genes across cancer lineages are ATM, ACC1, and JNK2. Each is linked with FGF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF23-to-partner and partner-to-FGF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FGF23-low versus FGF23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF23→partner) and Y-score (partner→FGF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.565	-3.156	.005	.018	3	2
UCEC	ACC1 →	+0.358	+2.000	.029	.032	3	1
UCEC	JNK2 →	+0.184	+2.700	.040	.006	3	1
UCEC	MSH2 →	-0.345	-2.000	<.001	.032	3	1
UCEC	MSH6 →	-0.528	-2.000	<.001	.032	3	1
UCEC	PR →	-0.233	-3.169	.039	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATM by FGF23 expression — UCEC

Explore this box plot interactively →