FGF23

Across TCGA cell cohorts, FGF23 RNA expression is significantly associated with the go_rna of many other GO terms, with 297 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FGF23-associated GO terms across cancer lineages are Extracellular matrix organization, Extracellular structure organization, and External encapsulating structure organization. Each is linked with FGF23 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGF23-to-partner and partner-to-FGF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Extracellular matrix organization grouped by FGF23-low versus FGF23-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF23→partner) and Y-score (partner→FGF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Extracellular matrix organization →	-0.146	-0.011	.006	.006	3	3
BONE	Extracellular structure organization →	-0.146	-0.011	.006	.006	3	3
BONE	External encapsulating structure organization →	-0.145	-0.011	.006	.006	3	3
BONE	Regulation of sodium ion export across plasma membrane →	-0.282	-0.016	<.001	.003	3	3
BONE	Positive regulation of sodium ion export across plasma membrane →	-0.282	-0.016	<.001	.003	3	3
LARGE_INTESTINE	Rostrocaudal neural tube patterning →	+0.098	+0.230	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

Extracellular matrix organization by FGF23 expression — BONE

Explore this box plot interactively →