FGF22

Across TCGA patient cohorts, FGF22 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,330 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FGF22-associated proteins across cancer lineages are CTSC, HSPA12B_S434, and ARHGAP35. Each is linked with FGF22 in more than 3 cancer types. Because this analysis shows association rather than direction, both FGF22-to-partner and partner-to-FGF22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FGF22 versus CTSC in GBM, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF22→partner) and Y-score (partner→FGF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CTSC →	-0.588	-0.335	.001	<.001	3	4
BRCA	HSPA12B_S434 →	+0.591	+0.195	<.001	<.001	3	3
BRCA	ARHGAP35 →	+0.337	+0.208	<.001	.001	3	3
GBM	P4HB →	-0.277	-0.220	.003	<.001	3	3
LSCC	CASKIN1_S787 →	+1.412	+0.197	.001	.006	3	3
BRCA	NAMPT →	-0.709	-0.236	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,330 associations by consensus.

FGF22 vs CTSC — GBM

Explore this scatter interactively →