FGF22

Across TCGA cell cohorts, FGF22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,036 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FGF22-associated GO terms across cancer lineages are Methylglyoxal metabolic process, CTP salvage, and Positive regulation of cation transmembrane transport. Each is linked with FGF22 in more than 11 cancer types. Because this analysis shows association rather than direction, both FGF22-to-partner and partner-to-FGF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methylglyoxal metabolic process grouped by FGF22-low versus FGF22-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF22→partner) and Y-score (partner→FGF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Methylglyoxal metabolic process →	+0.119	+0.415	<.001	.003	3	12
BONE	CTP salvage →	+0.104	+0.338	<.001	<.001	3	12
STOMACH	Positive regulation of cation transmembrane transport →	-0.110	-0.193	.002	.005	3	12
STOMACH	Epigenetic regulation of gene expression →	+0.057	+0.152	.004	.009	3	12
OVARY	U2-type prespliceosome assembly →	+0.114	+0.281	<.001	.005	3	11
SOFT_TISSUE	Positive regulation of monoatomic ion transmembrane transport →	-0.099	-0.271	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,036 associations by consensus.

Methylglyoxal metabolic process by FGF22 expression — BREAST

Explore this box plot interactively →