FGF22

Across TCGA cell cohorts, FGF22 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible FGF22-associated genes across cancer lineages are DEFA4, MS4A10, and RESP18. Each is linked with FGF22 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF22-to-partner and partner-to-FGF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by FGF22-low versus FGF22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF22→partner) and Y-score (partner→FGF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFA4 by FGF22 expression — LARGE_INTESTINE

Explore this box plot interactively →