FGF20

Across TCGA pan-cancer cohorts, FGF20 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FGF20’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGF20 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FGF20 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where FGF20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.317	<.001	11	view →
COAD	All	All	+0.635	.001	8	view →
THCA	All	II,III,IV	+0.582	<.001	8	view →
HNSC	All	II,III,IV	−0.132	.001	8	view →
BRCA	Female	All	−0.135	<.001	4	view →
READ	All	All	+1.782	.014	3	view →
LUAD	Female	All	+0.285	<.001	3	view →
KICH	Male	II,III,IV	−0.073	.001	3	view →
ESCA	All	II,III,IV	+1.120	.048	2	view →
UCEC	All	All	+1.032	.028	2	view →
STAD	All	All	+0.293	.031	2	view →
LUSC	All	III,IV	−0.251	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FGF20–KIRC

Open the KIRC breakdown →