FGF2

Across TCGA pan-cancer cohorts, FGF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FGF2 data layer compared with 15 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FGF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGF2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where FGF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.480	1.000	.005	30	view →
LUAD	DFS	Quartile	II,III,IV	0.580	0.997	.003	16	view →
LSCC	DFS	Quartile	II,III,IV	0.921	0.229	.024	3	view →
CCRCC	OS	Median	III,IV	1.000	0.842	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FGF2–UCEC (OS)

Open the UCEC breakdown →