FGF2

Across TCGA patient cohorts, FGF2 mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF2-associated genes across cancer lineages are BNIP3P41, TTTY12, and RNU7-193P. Each is linked with FGF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF2-to-partner and partner-to-FGF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by FGF2-low versus FGF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF2→partner) and Y-score (partner→FGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P41 →	+0.022	+5.308	<.001	.001	3	2
CESC	TTTY12 →	+0.060	+5.812	<.001	.003	3	1
CESC	RNU7-193P →	+0.522	+5.103	<.001	.008	3	1
CESC	LINC00293 →	+0.025	+5.418	<.001	.005	3	1
CESC	PMM2P1 →	+0.081	+6.342	<.001	.001	3	1
CESC	MIR4646 →	+0.641	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

BNIP3P41 by FGF2 expression — UCEC

Explore this box plot interactively →