FGF2

Across TCGA patient cohorts, FGF2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF2-associated genes across cancer lineages are mTOR_pS2448, TIGAR, and PAI-1. Each is linked with FGF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF2-to-partner and partner-to-FGF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FGF2-low versus FGF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF2→partner) and Y-score (partner→FGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.198	-2.980	.015	.036	3	1
UCEC	TIGAR →	+0.231	+3.196	.005	.010	3	1
UCEC	PAI-1 →	+0.417	+3.000	.027	.036	2	1
UCEC	VEGFR2 →	+0.327	+2.817	.045	.036	2	1
UCEC	EGFR_pY1068 →	-0.338	-3.169	.014	.020	1	1
UCEC	Notch1 →	+0.292	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

mTOR_pS2448 by FGF2 expression — UCEC

Explore this box plot interactively →