FGF19

Across TCGA pan-cancer cohorts, FGF19 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated FGF19 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FGF19 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FGF19 expression acts as an unfavorable survival marker.

HNSC are the cancer types where FGF19 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.118	0.768	<.001	48	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

FGF19–HNSC (OS)

Open the HNSC breakdown →