FGF19

Across TCGA patient cohorts, FGF19 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FGF19-associated genes across cancer lineages are RNY4P34, RNU6-597P, and C7orf66. Each is linked with FGF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF19-to-partner and partner-to-FGF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P34 grouped by FGF19-low versus FGF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF19→partner) and Y-score (partner→FGF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY4P34 →	+0.972	+4.279	.007	.008	3	1
UCEC	RNU6-597P →	+1.079	+4.448	<.001	.006	3	1
UCEC	C7orf66 →	+0.419	+4.256	.003	.008	3	1
UCEC	RNU6-541P →	+0.855	+5.223	<.001	.001	3	1
UCEC	MIR920 →	+0.885	+4.719	.003	.003	3	1
UCEC	AK4P5 →	+0.217	+5.262	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

RNY4P34 by FGF19 expression — UCEC

Explore this box plot interactively →