FGF19

Across TCGA cell cohorts, FGF19 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,539 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FGF19-associated GO terms across cancer lineages are Regulation of cytotoxic T cell degranulation, Negative regulation of cytotoxic T cell degranulation, and Protein exit from endoplasmic reticulum. Each is linked with FGF19 in more than 4 cancer types. Because this analysis shows association rather than direction, both FGF19-to-partner and partner-to-FGF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytotoxic T cell degranulation grouped by FGF19-low versus FGF19-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF19→partner) and Y-score (partner→FGF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of cytotoxic T cell degranulation →	+1.813	+2.230	<.001	.001	3	5
LIVER	Negative regulation of cytotoxic T cell degranulation →	+1.813	+2.230	<.001	.001	3	5
LIVER	Protein exit from endoplasmic reticulum →	+0.145	+2.826	.003	.003	3	5
BLOOD_Lymphoma	Regulation of RNA export from nucleus →	+0.070	+0.017	.002	.004	3	5
BLOOD_Myeloma	Hippocampus development →	+0.062	+0.033	.002	.001	3	4
OESOPHAGUS	Vesicle docking involved in exocytosis →	+0.057	+1.570	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,539 associations by consensus.

Regulation of cytotoxic T cell degranulation by FGF19 expression — LIVER

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