FGF14

Across TCGA pan-cancer cohorts, FGF14 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGF14 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FGF14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FGF14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, SKCM, and UCEC are the cancer types where FGF14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
SKCM	DFS	Median	All	0.236	0.645	.004	11	view →
UCEC	DFS	Median	All	1.000	0.631	.015	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
READ	DFS	Median	III,IV	0.182	0.745	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGF14–ESCA (OS)

Open the ESCA breakdown →