FGF14

Across TCGA patient cohorts, FGF14 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF14-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and FASN. Each is linked with FGF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF14-to-partner and partner-to-FGF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FGF14-low versus FGF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF14→partner) and Y-score (partner→FGF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.572	+3.341	.019	.005	3	2
UCEC	4E-BP1 →	+0.262	+1.807	.019	.027	3	2
COAD	FASN →	+0.476	+2.815	.026	.036	3	1
COAD	ASNS →	+0.628	+2.815	.003	.036	2	2
UCEC	EGFR_pY1068 →	-0.275	-2.321	.008	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-1.794	.015	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by FGF14 expression — UCEC

Explore this box plot interactively →