FGD6

Across TCGA patient cohorts, FGD6 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD6-associated genes across cancer lineages are eEF2, GAPDH, and INPP4B. Each is linked with FGD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD6-to-partner and partner-to-FGD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FGD6-low versus FGD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD6→partner) and Y-score (partner→FGD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.328	+1.398	.001	.004	3	3
COAD	GAPDH →	+0.776	+2.182	<.001	.033	3	3
COAD	INPP4B →	-0.487	-3.169	.003	.018	3	3
UCEC	Notch1 →	+0.129	+1.939	.001	.002	3	3
COAD	Caspase-7-cleavedD198 →	+1.347	+2.330	<.001	.020	3	3
UCEC	4E-BP1 →	+0.268	+3.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

eEF2 by FGD6 expression — UCEC

Explore this box plot interactively →