FGD6

Across TCGA cell cohorts, FGD6 mutation is significantly associated with the RNA expression of many other genes, with 522 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD6-associated genes across cancer lineages are P2RY13, SPAG11B, and ZNF735. Each is linked with FGD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGD6-to-partner and partner-to-FGD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY13 grouped by FGD6-low versus FGD6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD6→partner) and Y-score (partner→FGD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	2
LUNG_SCLC	SPAG11B →	+0.951	+3.256	.005	.005	3	2
KIDNEY	ZNF735 →	+0.023	+5.000	<.001	.005	3	1
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1
SKIN	OR6B3 →	+0.081	+4.437	<.001	.004	3	1
SKIN	LCE4A →	+0.038	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 522 associations by consensus.

P2RY13 by FGD6 expression — SKIN

Explore this box plot interactively →