FGD4

Across TCGA pan-cancer cohorts, FGD4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FGD4 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FGD4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FGD4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and COAD are the cancer types where FGD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.515	0.276	<.001	63	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.231	<.001	44	view →
COAD	DFS	Median	All	1.000	0.894	.030	36	view →
LUAD	OS	Median	III,IV	0.252	0.843	.016	25	view →
CCRCC	DFS	Median	All	0.623	0.841	.005	8	view →
GBM	OS	Median	All	0.364	0.678	.004	5	view →
HNSC	OS	Median	IV	0.846	0.639	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FGD4–PDAC (DFS)

Open the PDAC breakdown →