FGD4

Across TCGA patient cohorts, FGD4 mutation is significantly associated with the RNA expression of many other genes, with 2,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD4-associated genes across cancer lineages are RN7SL98P, ENO1, and MIR7156. Each is linked with FGD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD4-to-partner and partner-to-FGD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL98P grouped by FGD4-low versus FGD4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD4→partner) and Y-score (partner→FGD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL98P →	+0.179	+4.150	<.001	.003	3	3
UCEC	ENO1 →	+0.418	+2.753	.006	<.001	3	3
COAD	MIR7156 →	+0.931	+5.693	<.001	.003	3	2
BRCA	LINC01699 →	+0.232	+3.941	<.001	.005	3	2
BRCA	RNU6-207P →	+0.279	+4.986	<.001	.003	3	2
BRCA	MRPS17P9 →	+0.094	+3.941	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,110 associations by consensus.

RN7SL98P by FGD4 expression — LUSC

Explore this box plot interactively →