FGD4

Across TCGA patient cohorts, FGD4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD4-associated genes across cancer lineages are TFRC, MEK1, and c-Kit. Each is linked with FGD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD4-to-partner and partner-to-FGD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by FGD4-low versus FGD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD4→partner) and Y-score (partner→FGD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.371	+2.459	.034	.018	3	3
UCEC	MEK1 →	+0.336	+3.000	.005	<.001	3	2
UCEC	c-Kit →	-0.158	-2.102	.040	.016	3	2
UCEC	Cyclin-B1 →	+0.512	+1.652	.005	.006	3	2
UCEC	EGFR →	-0.186	-2.321	<.001	.005	3	1
UCEC	eIF4E →	+0.147	+1.652	.033	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TFRC by FGD4 expression — UCEC

Explore this box plot interactively →