FGD3

Across TCGA patient cohorts, FGD3 mutation is significantly associated with the RNA expression of many other genes, with 2,539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD3-associated genes across cancer lineages are PHF5A, KCTD9, and TNFSF9. Each is linked with FGD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD3-to-partner and partner-to-FGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by FGD3-low versus FGD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD3→partner) and Y-score (partner→FGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.429	+3.258	<.001	<.001	3	3
UCEC	KCTD9 →	+0.610	+2.283	<.001	<.001	3	3
UCEC	TNFSF9 →	+0.832	+3.000	<.001	<.001	3	3
UCEC	AOC2 →	+0.906	+1.776	<.001	<.001	3	3
UCEC	DDB2 →	+0.501	+2.392	<.001	<.001	3	3
UCEC	CDCA2 →	+0.720	+1.999	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,539 associations by consensus.

PHF5A by FGD3 expression — UCEC

Explore this box plot interactively →