FGD3

Across TCGA patient cohorts, FGD3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD3-associated genes across cancer lineages are PCNA, YAP_pS127, and MSH6. Each is linked with FGD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD3-to-partner and partner-to-FGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FGD3-low versus FGD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD3→partner) and Y-score (partner→FGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.318	+2.178	.006	.035	3	3
SKCM	YAP_pS127 →	-0.460	-3.000	.024	.035	3	2
UCEC	MSH6 →	-0.356	-2.222	<.001	.009	3	2
UCEC	Notch1 →	+0.116	+1.459	.011	.012	3	2
UCEC	Annexin-1 →	+0.682	+3.999	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.207	+1.874	.018	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PCNA by FGD3 expression — COAD

Explore this box plot interactively →