FGD3

Across TCGA cell cohorts, FGD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,870 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FGD3-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Establishment of epithelial cell apical/basal polarity, and Sensory perception of salty taste. Each is linked with FGD3 in more than 10 cancer types. Because this analysis shows association rather than direction, both FGD3-to-partner and partner-to-FGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by FGD3-low versus FGD3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD3→partner) and Y-score (partner→FGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.163	+1.458	.001	<.001	3	11
PANCREAS	Establishment of epithelial cell apical/basal polarity →	-0.207	-1.427	<.001	.002	3	11
URINARY_TRACT	Sensory perception of salty taste →	+1.199	+2.412	<.001	<.001	3	11
STOMACH	Negative regulation of mRNA catabolic process →	+0.072	+1.335	<.001	.002	2	11
LUNG_NSCLC_LUSC	Serotonin secretion →	+1.225	+0.998	.001	<.001	3	10
LUNG_NSCLC_LUSC	Serotonin production involved in inflammatory response →	+1.225	+0.998	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,870 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by FGD3 expression — PANCREAS

Explore this box plot interactively →