FGD3

Across TCGA cell cohorts, FGD3 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD3-associated genes across cancer lineages are PLVAP, RASGEF1C, and IFIT5. Each is linked with FGD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGD3-to-partner and partner-to-FGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLVAP grouped by FGD3-low versus FGD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD3→partner) and Y-score (partner→FGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLVAP →	+0.186	+3.761	.002	.001	3	1
LARGE_INTESTINE	RASGEF1C →	+0.237	+2.626	<.001	.006	3	1
LARGE_INTESTINE	IFIT5 →	+0.952	+3.067	.002	.009	3	1
LARGE_INTESTINE	PGRMC2 →	+0.662	+3.087	.002	.006	3	1
LARGE_INTESTINE	CPLX4 →	+0.029	+3.222	<.001	.002	3	1
LARGE_INTESTINE	ACER1 →	+0.064	+2.823	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

PLVAP by FGD3 expression — LARGE_INTESTINE

Explore this box plot interactively →