FGD2

Across TCGA patient cohorts, FGD2 mutation is significantly associated with the RNA expression of many other genes, with 2,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD2-associated genes across cancer lineages are RNU6-817P, TAF9, and RNU6-342P. Each is linked with FGD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FGD2-to-partner and partner-to-FGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-817P grouped by FGD2-low versus FGD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD2→partner) and Y-score (partner→FGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-817P →	+0.305	+1.464	.009	.003	3	4
UCEC	TAF9 →	+0.578	+1.893	<.001	<.001	3	3
HNSC	RNU6-342P →	+0.302	+3.826	<.001	.003	3	3
UCEC	NDUFA6 →	+0.465	+1.903	<.001	<.001	3	3
UCEC	BCAM →	-1.118	-1.871	<.001	<.001	3	3
UCEC	NRAV →	+0.384	+1.893	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,383 associations by consensus.

RNU6-817P by FGD2 expression — SKCM

Explore this box plot interactively →