FGD2

Across TCGA patient cohorts, FGD2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD2-associated genes across cancer lineages are INPP4B, Snail, and Caspase-8. Each is linked with FGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGD2-to-partner and partner-to-FGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by FGD2-low versus FGD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD2→partner) and Y-score (partner→FGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.318	-3.807	.004	<.001	3	2
UCEC	Snail →	-0.220	-2.057	.048	.001	3	2
UCEC	Caspase-8 →	-0.266	-2.973	.002	<.001	3	2
UCEC	C-Raf →	+0.159	+1.502	.001	.027	3	2
UCEC	14-3-3_beta →	-0.108	-2.195	.001	.009	3	2
UCEC	eEF2 →	+0.300	+1.440	.015	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

INPP4B by FGD2 expression — UCEC

Explore this box plot interactively →