FGD2

Across TCGA cell cohorts, FGD2 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD2-associated genes across cancer lineages are MORN4, FERD3L, and L3MBTL2. Each is linked with FGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGD2-to-partner and partner-to-FGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORN4 grouped by FGD2-low versus FGD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD2→partner) and Y-score (partner→FGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MORN4 →	+0.857	+3.212	.004	.006	3	2
STOMACH	FERD3L →	+0.136	+5.285	<.001	.003	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.679	+3.212	.001	.006	3	1
LARGE_INTESTINE	FNDC3A →	+0.608	+3.064	.001	.009	3	1
LARGE_INTESTINE	OCIAD1 →	+0.537	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TXNDC15 →	+0.623	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

MORN4 by FGD2 expression — LARGE_INTESTINE

Explore this box plot interactively →