FGD1

Across TCGA pan-cancer cohorts, FGD1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FGD1 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FGD1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGD1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BLCA show a favorable association.

COAD, LIHC, and HNSC are the cancer types where FGD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.184	0.710	<.001	13	view →
LIHC	OS	Median	All	0.255	0.773	.012	9	view →
HNSC	OS	Median	II,III,IV	0.196	0.710	.030	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
SCLC	OS	Median	All	0.846	0.316	.032	4	view →
BLCA	DFS	Median	II,III,IV	0.835	0.319	.030	4	view →
STAD	DFS	Median	III,IV	1.000	0.338	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FGD1–COAD (DFS)

Open the COAD breakdown →