FGB

Across TCGA pan-cancer cohorts, FGB Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated FGB data layer compared with 21 for mass-spec protein and 9 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FGB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGB expression acts as an unfavorable survival marker.

OV, ESCA, and LIHC are the cancer types where FGB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.140	0.541	.001	18	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	18	view →
LIHC	OS	Median	All	0.042	0.775	<.001	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
SARC	DFS	Median	All	0.101	0.611	.013	6	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

FGB–OV (DFS)

Open the OV breakdown →