FGB

Across TCGA pan-cancer cohorts, FGB mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated FGB data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FGB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGB expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

GBM, LUAD, and CCRCC are the cancer types where FGB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.372	0.687	<.001	24	view →
LUAD	OS	Quartile	II,III,IV	0.206	0.779	.003	22	view →
CCRCC	OS	Tertile	III,IV	0.444	0.839	.007	22	view →
LSCC	DFS	Median	II,III,IV	0.834	1.000	.005	18	view →
COAD	DFS	Tertile	All	0.861	1.000	.039	12	view →
UCEC	OS	Median	All	0.904	1.000	.008	10	view →
OV	DFS	Median	All	0.900	0.679	.022	8	view →
PDAC	OS	Quartile	All	0.635	1.000	.002	6	view →
HNSC	DFS	Median	II,III,IV	0.689	0.881	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

FGB–GBM (OS)

Open the GBM breakdown →