FGB

Across TCGA patient cohorts, FGB mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGB-associated genes across cancer lineages are p62 Lck ligand, PCNA, and ASNS. Each is linked with FGB in more than 1 cancer types. Because this analysis shows association rather than direction, both FGB-to-partner and partner-to-FGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FGB-low versus FGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGB→partner) and Y-score (partner→FGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.376	+1.678	.002	.023	3	2
UCEC	PCNA →	+0.268	+3.321	.001	.009	3	2
UCEC	ASNS →	+0.421	+2.584	.002	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.637	+2.087	.005	.005	3	2
UCEC	4E-BP1 →	+0.316	+1.904	.002	.029	3	2
LUSC	Akt_pS473 →	+0.586	+3.009	.037	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p62 Lck ligand by FGB expression — UCEC

Explore this box plot interactively →