FGA

Across TCGA pan-cancer cohorts, FGA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FGA data layer compared with 20 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FGA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGA expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

GBM, LUAD, and COAD are the cancer types where FGA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.310	0.642	<.001	27	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	22	view →
COAD	DFS	Median	All	0.888	1.000	.023	18	view →
LSCC	DFS	Median	II,III,IV	0.840	1.000	.007	16	view →
UCEC	OS	Median	All	0.907	1.000	.010	12	view →
CCRCC	DFS	Median	All	0.709	1.000	.010	6	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FGA–GBM (OS)

Open the GBM breakdown →