FFAR2

Across TCGA patient cohorts, FFAR2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FFAR2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Heregulin. Each is linked with FFAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FFAR2-to-partner and partner-to-FFAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FFAR2-low versus FFAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FFAR2→partner) and Y-score (partner→FFAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.107	-2.074	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.208	-2.087	.030	.005	3	1
UCEC	Heregulin →	-0.110	-2.102	.020	.016	3	1
UCEC	mTOR_pS2448 →	-0.122	-1.678	.033	.023	3	1
UCEC	Myosin-IIa →	+0.161	+1.492	.030	.036	3	1
UCEC	p62 Lck ligand →	+0.281	+2.710	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by FFAR2 expression — UCEC

Explore this box plot interactively →