FEZF2

Across TCGA cell cohorts, FEZF2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FEZF2-associated genes across cancer lineages are OR10G4, TRIM43B, and HSF5. Each is linked with FEZF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEZF2-to-partner and partner-to-FEZF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G4 grouped by FEZF2-low versus FEZF2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZF2→partner) and Y-score (partner→FEZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10G4 →	+0.006	+4.977	<.001	.007	3	2
LUNG_NSCLC_LUAD	TRIM43B →	+0.032	+3.857	<.001	.006	3	1
LUNG_NSCLC_LUAD	HSF5 →	+0.009	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.027	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	DTHD1 →	+0.128	+4.688	<.001	<.001	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.018	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR10G4 by FEZF2 expression — SKIN

Explore this box plot interactively →