FEZ2

Across TCGA patient cohorts, FEZ2 mutation is significantly associated with the RNA expression of many other genes, with 508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEZ2-associated genes across cancer lineages are RNA5SP410, MIR6853, and RNF166. Each is linked with FEZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEZ2-to-partner and partner-to-FEZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP410 grouped by FEZ2-low versus FEZ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZ2→partner) and Y-score (partner→FEZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP410 →	+0.679	+2.789	<.001	.001	3	2
BRCA	MIR6853 →	+0.459	+9.057	<.001	.003	3	1
UCEC	RNF166 →	+0.619	+3.480	<.001	.002	3	1
UCEC	SYVN1 →	+0.579	+3.480	<.001	.002	3	1
UCEC	CFAP100 →	-1.204	-3.448	.008	.005	3	1
UCEC	KIR3DL1 →	+0.238	+3.910	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 508 associations by consensus.

RNA5SP410 by FEZ2 expression — UCEC

Explore this box plot interactively →