FEZ2

Across TCGA patient cohorts, FEZ2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEZ2-associated genes across cancer lineages are Notch1, ATM, and ERK2. Each is linked with FEZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEZ2-to-partner and partner-to-FEZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FEZ2-low versus FEZ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZ2→partner) and Y-score (partner→FEZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.153	+2.820	.038	.035	3	1
UCEC	ATM →	-0.666	-3.321	.005	.010	3	1
UCEC	ERK2 →	+0.235	+3.321	.019	.010	2	1
UCEC	Lck →	+0.304	+3.321	.003	.010	2	1
UCEC	eIF4E →	+0.242	+3.321	.028	.010	1	1
UCEC	Caspase-7-cleavedD198 →	+1.499	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by FEZ2 expression — UCEC

Explore this box plot interactively →