FEZ1

Across TCGA patient cohorts, FEZ1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEZ1-associated genes across cancer lineages are ATM, eIF4E, and JNK_pT183_Y185. Each is linked with FEZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FEZ1-to-partner and partner-to-FEZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FEZ1-low versus FEZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZ1→partner) and Y-score (partner→FEZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.489	-1.514	.001	.015	3	3
COAD	eIF4E →	+0.234	+2.195	.005	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-2.807	.003	.003	3	2
UCEC	NF-kB-p65_pS536 →	-0.357	-2.321	.021	.033	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.512	-2.584	<.001	.001	3	2
UCEC	PCNA →	+0.268	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

ATM by FEZ1 expression — UCEC

Explore this box plot interactively →