FERMT3

Across TCGA patient cohorts, FERMT3 mutation is significantly associated with the RNA expression of many other genes, with 2,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FERMT3-associated genes across cancer lineages are LLPH, GLYCAM1, and FAM74A6. Each is linked with FERMT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FERMT3-to-partner and partner-to-FERMT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LLPH grouped by FERMT3-low versus FERMT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FERMT3→partner) and Y-score (partner→FERMT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LLPH →	+0.359	+3.023	.003	<.001	3	3
BLCA	GLYCAM1 →	+0.018	+4.040	<.001	.007	3	2
BLCA	FAM74A6 →	+0.020	+3.796	<.001	.002	3	2
LGG	YBX1P7 →	+0.090	+5.529	<.001	.004	3	2
UCEC	LIN7C →	+0.555	+2.223	<.001	<.001	3	2
UCEC	COX15 →	+0.484	+2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

LLPH by FERMT3 expression — UCEC

Explore this box plot interactively →