FERMT3

Across TCGA cell cohorts, FERMT3 mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FERMT3-associated genes across cancer lineages are FBXW10, ADAM7, and POLDIP3. Each is linked with FERMT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FERMT3-to-partner and partner-to-FERMT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by FERMT3-low versus FERMT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FERMT3→partner) and Y-score (partner→FERMT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.239	+3.906	<.001	<.001	3	2
LARGE_INTESTINE	ADAM7 →	+0.003	+2.538	<.001	.005	3	2
LARGE_INTESTINE	POLDIP3 →	+0.570	+3.192	.004	.007	3	1
LARGE_INTESTINE	RPL3 →	+0.459	+3.237	.009	.003	3	1
LARGE_INTESTINE	MTMR3 →	+0.631	+3.364	.006	.002	3	1
LARGE_INTESTINE	SAMM50 →	+0.600	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

FBXW10 by FERMT3 expression — LARGE_INTESTINE

Explore this box plot interactively →