FERMT2

Across TCGA patient cohorts, FERMT2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FERMT2-associated genes across cancer lineages are eIF4E, PCNA, and PDCD4. Each is linked with FERMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FERMT2-to-partner and partner-to-FERMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FERMT2-low versus FERMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FERMT2→partner) and Y-score (partner→FERMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+3.472	.013	.002	3	3
UCEC	PCNA →	+0.246	+2.459	.001	<.001	3	3
UCEC	PDCD4 →	-0.512	-2.000	.001	.029	3	2
UCEC	Rad50 →	-0.248	-1.861	.003	.049	3	2
UCEC	ATM →	-0.678	-2.070	<.001	.001	3	2
UCEC	4E-BP1 →	+0.280	+3.321	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by FERMT2 expression — UCEC

Explore this box plot interactively →