FERMT1

Across TCGA patient cohorts, FERMT1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FERMT1-associated genes across cancer lineages are Annexin_VII, FoxM1, and Notch1. Each is linked with FERMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FERMT1-to-partner and partner-to-FERMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by FERMT1-low versus FERMT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FERMT1→partner) and Y-score (partner→FERMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Annexin_VII →	-0.152	-3.807	.006	<.001	3	2
UCEC	FoxM1 →	+0.287	+2.247	.002	.001	3	2
UCEC	Notch1 →	+0.189	+2.128	<.001	.009	3	2
UCEC	Rad50 →	-0.240	-1.847	.007	.008	3	2
UCEC	Bak →	+0.281	+1.847	.002	.008	3	2
UCEC	Cyclin-E2 →	+0.233	+3.009	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Annexin_VII by FERMT1 expression — SKCM

Explore this box plot interactively →