FER1L5

Across TCGA pan-cancer cohorts, FER1L5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FER1L5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FER1L5 RNA is repressed in tumor relative to normal tissue. In most cancer types FER1L5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where FER1L5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FER1L5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.279	<.001	11	view →
KICH	Male	All	−0.588	<.001	10	view →
KIRC	Male	II,III,IV	−0.239	<.001	10	view →
BRCA	All	III,IV	−0.412	<.001	6	view →
HNSC	Male	All	+0.071	.002	5	view →
LIHC	Male	All	+0.033	.002	5	view →
LUAD	Female	II,III,IV	−0.138	.001	4	view →
LUSC	Female	All	−0.151	<.001	3	view →
PAAD	Female	All	+0.315	.024	2	view →
PRAD	All	All	−0.152	<.001	2	view →
CHOL	All	All	+0.120	.001	2	view →
STAD	Male	II,III,IV	+0.051	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FER1L5–THCA

Open the THCA breakdown →