FER

Across TCGA pan-cancer cohorts, FER mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FER data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FER mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FER expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where FER mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.978	0.817	.003	35	view →
LSCC	OS	Tertile	III,IV	0.347	0.868	.005	25	view →
PDAC	OS	Median	All	0.466	0.696	.005	18	view →
LUAD	OS	Median	All	0.903	0.772	.018	4	view →
GBM	DFS	Median	All	0.647	0.777	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FER–HNSC (OS)

Open the HNSC breakdown →