FER

Across TCGA patient cohorts, FER mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FER-associated genes across cancer lineages are RAD51, MEK1, and ATM. Each is linked with FER in more than 2 cancer types. Because this analysis shows association rather than direction, both FER-to-partner and partner-to-FER results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by FER-low versus FER-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FER→partner) and Y-score (partner→FER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RAD51 →	+0.203	+2.816	.031	.036	3	3
UCEC	MEK1 →	+0.432	+2.000	<.001	<.001	3	3
UCEC	ATM →	-0.573	-1.716	<.001	.003	3	3
LUAD	FOXO3a_pS318_S321 →	-0.117	-3.169	.035	.019	3	2
LUAD	JNK_pT183_Y185 →	-0.171	-3.169	.026	.019	3	2
UCEC	4E-BP1 →	+0.390	+4.029	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RAD51 by FER expression — LUSC

Explore this box plot interactively →