FENDRR

Across TCGA pan-cancer cohorts, FENDRR RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FENDRR data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FENDRR RNA is associated with better overall survival. In most high-consensus cancer types, elevated FENDRR expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, KIRP, and HNSC are the cancer types where FENDRR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.706	0.553	<.001	106	view →
KIRP	DFS	Median	II,III,IV	0.260	0.677	<.001	105	view →
HNSC	DFS	Median	IV	0.729	0.553	<.001	104	view →
UVM	OS	Median	All	0.547	0.828	<.001	99	view →
CESC	OS	Tertile	All	0.854	0.690	.001	30	view →
LUAD	OS	Median	II,III,IV	0.777	0.634	.003	28	view →
CHOL	DFS	Tertile	All	0.832	0.177	<.001	24	view →
ACC	DFS	Tertile	All	0.204	0.559	.020	23	view →
TGCT	DFS	Median	All	0.745	0.921	.005	18	view →
COAD	OS	Median	All	0.909	0.828	.006	14	view →
READ	DFS	Quartile	IV	0.912	0.444	.006	12	view →
THYM	DFS	Median	II,III,IV	0.811	0.982	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FENDRR–KIRC (OS)

Open the KIRC breakdown →