FEN1

Across TCGA pan-cancer cohorts, FEN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FEN1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FEN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FEN1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where FEN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.627	1.000	.045	2	view →
LUAD	OS	Tertile	All	0.722	1.000	.034	2	view →
LSCC	DFS	Tertile	All	0.892	0.653	.020	2	view →
PDAC	OS	Quartile	All	0.757	0.979	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FEN1–CCRCC (OS)

Open the CCRCC breakdown →