FEN1

Across TCGA patient cohorts, FEN1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,117 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FEN1-associated genes across cancer lineages are CENPM, MCM5, and CDKN3. Each is linked with FEN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both FEN1-to-partner and partner-to-FEN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FEN1 versus CENPM in GBM, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEN1→partner) and Y-score (partner→FEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CENPM →	+1.157	+0.472	<.001	<.001	3	10
HNSC	MCM5 →	+0.882	+0.394	<.001	<.001	3	10
LUAD	CDKN3 →	+1.206	+0.429	<.001	<.001	3	10
LUAD	GINS1 →	+1.236	+0.488	<.001	<.001	3	10
LUAD	E2F1 →	+1.165	+0.471	<.001	<.001	3	10
LUAD	CENPI →	+1.147	+0.500	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,117 associations by consensus.

FEN1 vs CENPM — GBM

Explore this scatter interactively →