FEN1

Across TCGA patient cohorts, FEN1 mutation is significantly associated with the RNA expression of many other genes, with 693 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEN1-associated genes across cancer lineages are MIR3925, SNX3P1Y, and RNU6-717P. Each is linked with FEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEN1-to-partner and partner-to-FEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3925 grouped by FEN1-low versus FEN1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEN1→partner) and Y-score (partner→FEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3925 →	+0.594	+5.144	<.001	.003	3	2
UCEC	SNX3P1Y →	+0.137	+5.019	<.001	.001	3	2
BRCA	RNU6-717P →	+0.413	+8.471	<.001	.005	3	2
UCEC	MIR194-1 →	+0.767	+2.987	<.001	<.001	3	2
UCEC	RPS6P20 →	+0.084	+2.299	.005	.004	3	2
COAD	MS4A18 →	+0.233	+3.862	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 693 associations by consensus.

MIR3925 by FEN1 expression — CESC

Explore this box plot interactively →