FEN1

Across TCGA cell cohorts, FEN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,526 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FEN1-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Negative regulation of cell cycle phase transition, and Positive regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with FEN1 in more than 19 cancer types. Because this analysis shows association rather than direction, both FEN1-to-partner and partner-to-FEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by FEN1-low versus FEN1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FEN1→partner) and Y-score (partner→FEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of cell cycle process →	+0.075	+1.369	<.001	<.001	3	20
PANCREAS	Negative regulation of cell cycle phase transition →	+0.074	+1.144	<.001	.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.226	+1.419	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Mitotic DNA replication →	+0.214	+1.241	<.001	<.001	3	20
PANCREAS	Positive regulation of chromosome separation →	+0.220	+1.390	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.244	+1.465	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,526 associations by consensus.

Negative regulation of cell cycle process by FEN1 expression — BREAST

Explore this box plot interactively →