FEM1C

Across TCGA pan-cancer cohorts, FEM1C mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FEM1C data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FEM1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FEM1C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, GBM, and LUAD are the cancer types where FEM1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.915	0.471	.001	62	view →
GBM	DFS	Tertile	All	0.193	0.577	.002	15	view →
LUAD	OS	Tertile	II,III,IV	0.838	0.248	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FEM1C–HNSC (OS)

Open the HNSC breakdown →