FEM1B

Across TCGA patient cohorts, FEM1B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEM1B-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and ER-alpha_pS118. Each is linked with FEM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both FEM1B-to-partner and partner-to-FEM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FEM1B-low versus FEM1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1B→partner) and Y-score (partner→FEM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.268	-2.321	.009	.006	3	1
UCEC	eIF4G →	+0.334	+2.321	.009	.034	3	1
UCEC	ER-alpha_pS118 →	-0.325	-3.321	.028	.010	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.321	.007	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.105	.013	.017	3	1
UCEC	GAPDH →	+0.438	+1.807	.048	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by FEM1B expression — UCEC

Explore this box plot interactively →